Anthelmintic Action Hom
Dec 28, 2021
kho
Tetraneem is administered by different routes of administration, and it has a therapeutic effect on animals poisoned by botulinum toxin; for mice given a lethal dose of botulinum, the survival rate of Tetraneem is up to six hours after the challenge. More than 80 percent ; treatment for botulism monkeys after 24 hours of challenge can cure more than half; it also has a protective effect on type C botulism. Combination with anti-toxin serum can significantly reduce the amount of anti-toxin serum. The botulism-induced mice had a significant antagonistic effect on the reduction of synaptic vesicles in the neuromuscular junction of the diaphragm caused by lilytridin. Experiments have shown that the density of synaptic vesicles in the synaptic area of the neuromuscular junction in normal mice is 184±37цm2/given only after tetrahydropyranin is given, the synaptic vesicles in the neuromuscular junction are significantly reduced, and the average density is 68±15/um2. The average density of mice that were given toxin after toxin were 137±18/μm2 and 130±26/μm2, respectively, which has certain significance for further exploration of the mechanism of action of lignephrin and botulinum toxin.
Tshuaj tua kab mob
Cov dej rho tawm ntawm neem bark, junzi, thiab betel txiv ntoo muaj inhibitory cuam tshuam rau qee yam kab mob ntawm daim tawv nqaij hauv lub raj kuaj.
Lub gallbladder excitement
Kev txhaj tshuaj Betelnut tuaj yeem ua kom pom tseeb rau cov leeg nqaij hauv lub gallbladder hauv guinea npua los yog hauv vivo gallbladders ntawm miv thiab dev, ua rau muaj zog contraction thiab ua rau cov kua dej tawm ntawm lub gallbladder. Tsis muaj kev cuam tshuam rau cov kua tsib. Rhubarb txhaj tshuaj tuaj yeem txhawb nqa cov kua tsib. Yog tias ob qho tib si siv tsis tu ncua, nws tuaj yeem ua rau lub siab ntawm cov kab mob hauv cov kab mob hauv lub sijhawm luv luv rau cov dev lossis miv, ua kom cov kua tsib tso tawm, thiab pab txhawb kev tawm ntawm cov pob zeb hauv cov kua tsib. Betel txiv ntoo muaj qee yam kev cuam tshuam rau tib neeg lub gallbladder, uas tsis muaj zog dua li cov dev. Nws yog kev kho mob nrog lwm cov tshuaj suav tshuaj thiab tuaj yeem txhawb nqa kev tso tawm ntawm biliary roundworms lossis pob zeb. Betel txiv ntoo muaj cov nyhuv cholinergic, uas zoo ib yam li pilocarpine thiab muscarinic. Nws excites M choline receptors thiab tseem muaj cov nyhuv cholinergic ntawm lub hauv nruab nrab paj hlwb. Kev txhaj tshuaj me me ntawm arecoline hauv miv tuaj yeem ua rau cortex Nyob rau hauv wakefulness teb, atropine tuaj yeem txo lossis thaiv cov nyhuv no. Arecoline kuj muaj cov nyhuv ntawm stimulating N{0}}choline receptors.
Toxic nyhuv
Muaj anthelmintics
Ob peb anthelmintics (5 duab)
Neem bark decoction tuaj yeem ua rau ntuav hauv cov dev ntawm 15 g / kg, thiab cov koob tshuaj tuag rau luav yog ntau tshaj 40 g / kg. Lub siab ntev ntawm cov tsiaj yuav txawv me ntsis vim kev noj zaub mov zoo thiab lub cev muaj zog. Chuanmusu yog tswj hwm rau dev thiab miv los ntawm kev tswj hwm intragastric hauv ntau koob. Cov ntshav siab txo qis tuaj yeem nce ntxiv nrog cov koob tshuaj ntxiv, cov ntshav siab tuaj yeem poob mus rau xoom sharply, ua pa thiab lub plawv dhia nres, lub ntsws thiab plab hnyuv los ntshav. Kev tshuaj xyuas microscopic qhia tias cov ntshav los ntawm kev puas tsuaj rau phab ntsa ntawm cov hlab ntsha. Kev ua pa tsis ua haujlwm feem ntau yog tshwm sim los ntawm qhov ncaj qha inhibition ntawm qhov chaw ua pa. Nicosamide muaj kev cuam tshuam me ntsis ntawm kev nyuaj siab ua pa los ntawm nws. Subacute toxicity thwmsim qhia tias Chuanzhong tuaj yeem nce glutathione hauv nas thiab liab. Cov kev hloov pauv pathological ntawm daim siab yog qhov pom tseeb dua li lwm yam kabmob, thiab muaj xim av - cov khoom daj tso rau ntawm vascular intima. Npua tshuaj lom los ntawm kev tswj hwm qhov ncauj ntawm cov ntsiav tshuaj Chuanmeisu pom kev tshee tshee, kev txav mus los, thiab paroxysmal convulsions. Cov menyuam yaus uas muaj tshuaj lom ua rau muaj kev tsis sib haum xeeb, delirium, lethargy, cov menyuam kawm ntawv dilated, qeeb teb rau lub teeb, thiab lwm yam, uas tej zaum yuav muaj feem xyuam rau cov purity ntawm cov tshuaj, ntau npaum li cas daim ntawv thiab tsiaj hom.
Kev siv tshuaj lom ntawm ligneidin tuaj yeem ua rau tsis muaj zog (tus tuag tes tuag taw, poob taub hau, poob ntawm daim tawv muag), ua pa nyuaj, thiab twitching ntawm cov ceg ntawm nas, npua, dev thiab liab.
Cov kev sim tau ua pov thawj tias Chuanzhong yog cov kab mob neuromuscular kis tau tus mob uas xaiv ua rau ntawm daim nyias nyias presynaptic. Nws tuaj yeem thaiv qhov kev sib kis ntawm cov hlab ntsha thiab cov leeg ntawm nas thiab nas, uas yog qhov ua rau cov leeg tsis muaj zog hauv cov liab thiab lwm yam tsiaj. Electron microscopic soj ntsuam pom tias Tetranead muaj kev hloov pauv tseem ceeb hauv cov qauv submicroscopic ntawm presynaptic membrane ntawm neuromuscular junctions hauv nas thiab nas.
Kev txhaj tshuaj subcutaneous hauv nas ua qhov tsawg kawg nkaus ntawm cov tshuaj tua kab mob Gentleman Water Extract 20g / kg, ua rau mob me me thoob plaws hauv lub cev, thiab tom qab ntawd ua pa nres, ua rau Gentleman qhov ncauj 26.6g / kg rau tus dev, uas tuaj yeem ua rau ntuav thiab dysphoria. Arecoline tuaj yeem txhim kho plab hnyuv peristalsis thiab ua rau raws plab. Mob plab hnyuv, mob plab hnyav, xeev siab, ntuav thiab lwm yam tsos mob feem ntau tshwm sim.