Streptomycin Sulfate
May 17, 2022
Antibacterial spectrum: streptomycin sulfate yog qhov nqaim-spectrum aminoglycoside (tab sis cov kab mob tua kab mob yog dav dua penicillin), feem ntau tawm tsam aerobic Gram-negative kab mob. Nws muaj cov tshuaj tua kab mob zoo rau ntau yam kab mob Gram-negative, xws li Escherichia coli, Pasteurella, Salmonella, Brucella, Proteus, thiab lwm yam. Nws muaj cov nyhuv tsis zoo rau feem ntau cov kab mob gram-zoo cocci xws li Staphylococcus aureus. Nws muaj cov nyhuv bactericidal synergistic ua ke nrog penicillin, thiab tseem zoo tiv thaiv Leptospira. Streptococcus, Pseudomonas aeruginosa thiab cov kab mob anaerobic tiv taus streptomycin sulfate.
Qhov qis concentration ntawm streptomycin sulfate yog bacteriostatic, thiab siab dua concentration yog bactericidal; Nws tsis muaj txiaj ntsig tiv thaiv kab mob, rickettsia, thiab kab mob. Cov tshuaj tua kab mob yog qhov muaj zog tshaj plaws nyob rau hauv qhov tsis muaj zog alkaline (pH7.8) ib puag ncig, thiab kev ua haujlwm txo qis hauv acidic (hauv qab pH6) ib puag ncig. Cov kab mob tuaj yeem txhim kho tau yooj yim tom qab raug streptomycin sulfate, uas sai dua penicillin thiab tuaj yeem ncav cuag qib siab ntawm kev tiv thaiv nyob rau lub sijhawm luv luv. Vim tias streptomycin sulfate tau siv dav hauv cov chaw kho tsiaj rau lub sijhawm ntev, cov tshuaj tiv thaiv kab mob yog dav dav, thiab muaj qee qhov kev sib tw nrog kanamycin thiab gentamicin. Cov kab mob resistant rau tshuaj tua kab mob thiab gentamicin kuj resistant rau streptomycin sulfate; tab sis cov kab mob resistant rau streptomycin tseem rhiab heev rau gentamicin thiab kanamycin. Feem ntau ntawm cov chaw kho mob yog cov resistant rau plasmid-encoded enzymes, thiab cov streptomycin tsis kam genes ntawm cov plasmids feem ntau txuas rau sulfonamide, ampicillin thiab tetracycline kuj noob. Yog li ntawd, streptomycin sulfate feem ntau ua ke nrog lwm cov tshuaj tua kab mob los tiv thaiv kab mob pathogenic los ntawm chromosomal hloov tsis kam.